Flights from Santa Ana John Wayne Airport to Iowa

Travellers and cabin class

Flight deals from Santa Ana John Wayne Airport to Iowa

Looking for cheap tickets from Santa Ana John Wayne Airport to Iowa, or a last-minute trip? Find the lowest prices on one-way and return tickets right here.

Flying from Santa Ana John Wayne Airport to Iowa

Arm yourself with these facts on the fly.
Cheapest flight foundSAR 442, Des Moines
Cheapest month to flyAugust
Average flight time3 hrs, 19 mins
Average flights per week3
Most popular airlineAllegiant Air

Frequently asked questions

Yes - direct flights currently operate from Santa Ana John Wayne Airport to Des Moines Airport in Iowa.
We looked at all of the upcoming return flights from Santa Ana John Wayne Airport to Iowa we could find over the next 12 months. It looks like SAR 442 is the best price. This is good, compared to the average Iowa ticket price of SAR 1,034.
The cheapest month to fly from Santa Ana John Wayne Airport to Cedar Rapids Airport is currently June.
The cheapest month to fly from Santa Ana John Wayne Airport to Des Moines Airport is currently August.
The cheapest month to fly from Santa Ana John Wayne Airport to Mason City Airport is currently June.
And the cheapest month to fly from Santa Ana John Wayne Airport to Sioux City Airport is usually July.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Santa Ana John Wayne Airport to Iowa on Thursday, 28 August 2025.
If you're flying from Santa Ana John Wayne, the cheapest city in Iowa to fly into is Des Moines. The cheapest airport serving Des Moines at the moment is Des Moines.
The average flight time between Santa Ana John Wayne Airport and Iowa is 3 hours and 19 minutes.