Flights from Knoxville to South Carolina

Travellers and cabin class

Flight deals from Knoxville to South Carolina

Looking for cheap tickets from Knoxville to South Carolina, or a last-minute trip? Find the lowest prices on one-way and return tickets right here.

Flying from Knoxville to South Carolina

Arm yourself with these facts on the fly.
Cheapest flight foundSAR 856, Myrtle Beach
Cheapest month to flyAugust
Cheapest airport to fly fromKnoxville

Frequently asked questions

We looked at all of the upcoming return flights from Knoxville to South Carolina we could find over the next 12 months. It looks like SAR 856 is the best price. This is good, compared to the average South Carolina ticket price of SAR 1,426.
The cheapest month to fly from Knoxville to Charleston Airport is currently August. The cheapest month to fly from Knoxville to Columbia Metropolitan Airport is usually June. And the cheapest month to fly from Knoxville to Myrtle Beach International Airport is usually August.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Knoxville to South Carolina on Friday, 1 August 2025.
Currently, there aren't any direct flights from Knoxville to South Carolina, but you can still fly with a stopover.
If you're flying from Knoxville, the cheapest city in South Carolina to fly into is Myrtle Beach. The cheapest airport serving Myrtle Beach at the moment is Myrtle Beach International .